If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient’s cancer treatment on commonly disrupted genes and pathways.
Exploiting the use of DNA single- and double-strand breaking forms of the I-SceI endonuclease to stimulate homologous recombination and gene targeting in budding yeast and in human cells, the research of Samantha S. Katz in Francesca Storici’ lab provides new mechanistic insights into the process of nick-induced DNA recombination and on the function of nicking enzymes in genetic engineering.
Taking a DNA molecule into the vicinity of a homologous target gene by a DNA aptamer provides a many-fold enhancement of gene correction frequency at that genetic locus. Aptamer-guided gene targeting, or AGT, is a novel approach for genetic engineering developed by Patrick Ruff in Francesca Storici’s group.
Competition may have a high cost for at least one species of tropical seaweed. Researchers examining the chemical warfare taking place on Fijian coral reefs have found that one species of seaweed increases its production of noxious anti-coral compounds when placed into contact with reef-building corals, but at the same time becomes more attractive to herbivorous fish.
Natalie Saini receives top Suddath Symposium graduate student award
Georgia Tech faculty continue to be recognized as among the most respected in their field. Last month, the American Association for the Advancement of Science (AAAS) named four — in biology, computing and engineering — to its 2013 class of fellows
John McDonald, professor in the School of Biology and director of the Integrated Cancer Research Center, has also spent many years as the chief scientific officer for Georgia Tech’s Ovarian Cancer Institute.
Funding for research is a highly competitive endeavor under the best of circumstances. For Georgia Tech doctoral student Troy Alexander, a new avenue for funding has opened for his latest project that seeks to accelerate the discovery of new medicines for the treatment of cancer and infectious diseases by studying Fijian red algae.
Danielle Dixson is a new faculty member in the School of Biology this year, but she’s not new to Georgia Tech. She spent the previous two years as a post-doctoral fellow in Professor Mark Hay’s lab. Before that she received her Ph.D. from James Cook University in Australia and her B.S. from the University of Tampa. One might say she was brought up with biology in her future … the Minnesota Zoo was right behind her back fence as a kid.
Two proposals by Georgia Tech researchers, Dr. Frank Stewart (Assistant Professor, School of Biology) and Dr. Kostas Konstantinidis (Carlton S. Wilder Assistant Professor, Civil and Environmental Engineering; joint appointment in Biology; http://enve-omics.gatech.edu), have been selected for the Department of Energy's 2014 Community Science Program.